APH 2003, 61, 91-100:
Study of new explanatory mechanisms in the relation between job stress and cardiovascular diseases.
E. Clays, R. Mak, J. Delanghe, L. Van Renterghem, F. Kittel, F. Leynen, G. De Backer
Keywords: Job stress, cardiovascular diseases, inflammation, infection
This study explores whether bio-markers of chronic inflammation and
chronic infection - beside the classical cardiovascular risk factors
- can serve as alternative intervening mechanisms in the link between
job stress and cardiovascular diseases. Exposure to job stress could
make subjects more prone to infection and/or by a reduced immune system
to chronic inflammation.
The assumed relation between job stress and chronic inflammation and
infection has been tested in a subsample from the BELSTRESS study
of 1338 male subjects. Job stress was assessed by the ,,Job Content
Questionnaire". Participants underwent a biomedical examination
and blood samples were drawn and analysed on bio-markers of chronic
inflammation (high sensitivity C-reactive protein, plasma fibrinogen
and Serum amyloid A) and of chronic infection (titres against Chlamydia
pneumoniae, Cytomegalovirus en Helicobacter pylori).
Analyses of variance and logistic regressions did not yield any consistent
results as for the association between dimensions of job stress and
bio-markers of chronic inflammation and infection, neither in univariate
nor in multivariate analyses.
These study results can by no means support the hypothesis according
to which exposure to job stress is related to chronic inflammation
and infection. Future research is needed to further explore the model
proposed. Limitations of the study are discussed.