APH 2003, 61, 191-200:
Valid Belgian population frequency data on HLA A-B-DR haplotypes by means of family studies.
G. Mertens, Z. Berneman, B. Vandekerckhove, MP Edmons
Keywords: HLA, haplotype, Belgian, population genetics
In order to obtain reliable haplotype frequencies, 2251 Belgians belonging to the families of 468 haematological patients were typed for HLA A, B and DR. Three-locus haplotypes were determined by segregation analysis and a population genetic study was performed on the haplotypes of the 936 parents of the patients. No significant deviations from Hardy-Weinberg equilibrium were observed, showing the data to be representative for the population. Of the 518 observed haplotypes, 130 had a frequency of above 0.2% and represent 68.7% of the population. In forensic practice, the frequency of the other haplotypes can be set conservatively at 0.2%. In this way, with 99.32% of heterozygotes and a polymorphism information content of 99.05%, the HLA A-B-DR haplotype adds significant statistical weight in complex paternity cases. These data are also of interest in stem cell donor search, matching for organ transplantations and anthropological research.