APH 1997, 55, 313-321:

Evaluation of the use made of monoclonal mixture for detection of respiratory viruses.

M. Ieven, D. Provinciael, and H. Goossens

Keywords: respiratory viruses, diagnostics, monoclonal antibodies

During the winter of 1996-1997, current techniques for detection of respiratory viruses and monoclonal mixtures of two different companies were used on a limited number of nasopharyngeal aspiration samples (N = 311). The conclusions of the study are:
1. monoclonal mixtures can be recommended for detection of RSV and influenza A and B;
2. there weren't any significant differences between the reactives of both companies;
3. reduction of working time rose in relation to a decreasing percentage of positive samples;
4. studying a larger sample increased the number of positive samples by detecting an additional number of poorly positive samples;
5. in this study, the number of samples positive for the parainfluenza virus, adenovirus and rhinovirus, was too small to allow any conclusions. These fragmentary results confirm previous results showing the low sensitivity of immunofluerescence on the samples, most likely due to samples and virusses rather than to sera.